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			</style>[an error occurred while processing this directive]<div class="content-width"><ol class="breadcrumb text-uppercase"><li><a href="/">Home</a></li><li><a href="/aboutus/">About Us</a></li><li><a href="/people/">People</a></li><li><a href="/people/research.html">Research</a></li><li><a href="/people/Gary.Mirams"><span itemprop="name">Gary Mirams</span></a></li><li class="active">Publications</li></ol></div><!-- MOBILE NAVIGATION --><div class="content-width space-below mobile-menu-placeholder visible-xs visible-sm"></div><!-- COLUMNS --><div class="container-fluid content-width"><div class="row"><div class="col-xs-12 col-md-9 col-md-push-3" id="maincontent"><!-- CONTENT (Column 2) --><div class="page-title"><h1>Gary Mirams : Publications
</h1></div><div role="toolbar" class="btn-toolbar"><div class="btn-group"><a href="/people/publications/date/Gary.Mirams.html" aria-hidden="true" type="button" class="btn btn-default"><span class="glyphicon glyphicon-sort-by-attributes"></span> By date</a><a href="/people/publications/title/Gary.Mirams.html" aria-hidden="true" type="button" class="btn btn-oxford-blue"><span class="glyphicon glyphicon-sort-by-attributes"></span> By title</a><a href="/people/publications/type/Gary.Mirams.html" aria-hidden="true" type="button" class="btn btn-default"><span class="glyphicon glyphicon-sort-by-attributes"></span> By type</a><a href="/people/publications/bibtex/Gary.Mirams.html" aria-hidden="true" type="button" class="btn btn-default"><span class="glyphicon glyphicon-file"></span> BibTex</a></div></div><p></p><ul class="list-unbulleted list-unbulleted-spaced"><li>
	
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	<p class="publicationTitle"> <strong>
            A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to Cardiac Ionic Channel Modelling </strong> </p>
	    <p class="publicationAuthors"> <em> A. Sher&#x201a; K. Wang&#x201a; A. Wathen&#x201a; P.J. Maybank&#x201a; G.R. Mirams&#x201a; D. Abramson&#x201a; D. Noble and D.J. Gavaghan  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Future Generation Computer Systems</em>.
        
            Vol. 29.
        
            No. 2.
        
                Pages 591&#x2212;598.
            2013.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication5397-abstract.html">
			Details <span class="sr-only" > about <em> A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to Cardiac Ionic Channel Modelling  </em></span> </a> |
			<a href="/publications/publication5397.bib">
			BibTeX  <span class="sr-only" > data for <em> A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to Cardiac Ionic Channel Modelling  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1016/j.future.2011.09.006">
		DOI (10.1016/j.future.2011.09.006)
		</a> 
		
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	<p class="publicationTitle"> <strong>
            A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L&#x2212;type Calcium Channel Modelling </strong> </p>
	    <p class="publicationAuthors"> <em> A. Sher&#x201a; K. Wang&#x201a; A. Wathen&#x201a; G. Mirams&#x201a; D. Abramson and D. Gavaghan  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>2010 IEEE Sixth International Conference on e ??: Science</em>.
        
                Pages 176&#x2013;181.
            2010.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication5038-abstract.html">
			Details <span class="sr-only" > about <em> A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L&#x2212;type Calcium Channel Modelling  </em></span> </a> |
			<a href="/publications/publication5038.bib">
			BibTeX  <span class="sr-only" > data for <em> A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L&#x2212;type Calcium Channel Modelling  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1109/eScience.2010.56">
		DOI (10.1109/eScience.2010.56)
		</a> 
					| <a href="http://www.computer.org/portal/web/csdl/doi/10.1109/eScience.2010.56"> Link <span class="sr-only" > to <em> A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L&#x2212;type Calcium Channel Modelling  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            A computational study of discrete mechanical tissue models </strong> </p>
	    <p class="publicationAuthors"> <em> P Pathmanathan&#x201a; J Cooper&#x201a; A Fletcher&#x201a; G Mirams&#x201a; P Murray&#x201a; J Osborne&#x201a; J Pitt&#x2212;Francis&#x201a; A Walter and S J Chapman  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Physical Biology</em>.
        
            Vol. 6.
        
            No. 3.
        2009.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication3106-abstract.html">
			Details <span class="sr-only" > about <em> A computational study of discrete mechanical tissue models  </em></span> </a> |
			<a href="/publications/publication3106.bib">
			BibTeX  <span class="sr-only" > data for <em> A computational study of discrete mechanical tissue models  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1088/1478-3975/6/3/036001">
		DOI (10.1088/1478-3975/6/3/036001)
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	<p class="publicationTitle"> <strong>
            A hybrid approach to multi&#x2212;scale modelling of cancer </strong> </p>
	    <p class="publicationAuthors"> <em> J. M. Osborne&#x201a; A. Walter&#x201a; S. K. Kershaw&#x201a; G. R. Mirams&#x201a; A. G. Fletcher&#x201a; P. Pathmanathan&#x201a; D. Gavaghan&#x201a; O. E. Jensen&#x201a; P. K. Maini and H. M. Byrne  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Philosophical Transactions of the Royal Society A: Mathematical&#x201a; Physical and Engineering Sciences</em>.
        
            Vol. 368.
        
            No. 1930.
        
                Pages 5013&#x2013;5028.
            November,
            2010.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication5034-abstract.html">
			Details <span class="sr-only" > about <em> A hybrid approach to multi&#x2212;scale modelling of cancer  </em></span> </a> |
			<a href="/publications/publication5034.bib">
			BibTeX  <span class="sr-only" > data for <em> A hybrid approach to multi&#x2212;scale modelling of cancer  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1098/rsta.2010.0173">
		DOI (10.1098/rsta.2010.0173)
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	<p class="publicationTitle"> <strong>
            A multiple timescale analysis of a mathematical model of the Wnt/<span style="font-family: serif">&#x03b2;</span>&#x2212;catenin signalling pathway </strong> </p>
	    <p class="publicationAuthors"> <em> G. R. Mirams&#x201a; H. M. Byrne and J. R. King  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Journal of mathematical biology</em>.
        
            Vol. 60.
        
            No. 1.
        
                Pages 131&#x2013;160.
            September,
            2009.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication5032-abstract.html">
			Details <span class="sr-only" > about <em> A multiple timescale analysis of a mathematical model of the Wnt/<span style="font-family: serif">&#x03b2;</span>&#x2212;catenin signalling pathway  </em></span> </a> |
			<a href="/publications/publication5032.bib">
			BibTeX  <span class="sr-only" > data for <em> A multiple timescale analysis of a mathematical model of the Wnt/<span style="font-family: serif">&#x03b2;</span>&#x2212;catenin signalling pathway  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1007/s00285-009-0262-y">
		DOI (10.1007/s00285-009-0262-y)
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	<p class="publicationTitle"> <strong>
            A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt </strong> </p>
	    <p class="publicationAuthors"> <em> GR Mirams&#x201a; AG Fletcher&#x201a; PK Maini and HM Byrne  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Journal of Theoretical Biology</em>.
        
            Vol. 312.
        
            No. 7.
        
                Pages 143&#x2212;156.
            2012.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication6210-abstract.html">
			Details <span class="sr-only" > about <em> A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt  </em></span> </a> |
			<a href="/publications/publication6210.bib">
			BibTeX  <span class="sr-only" > data for <em> A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1016/j.jtbi.2012.08.002">
		DOI (10.1016/j.jtbi.2012.08.002)
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	<p class="publicationTitle"> <strong>
            A web portal for in&#x2212;silico action potential predictions </strong> </p>
	    <p class="publicationAuthors"> <em> Geoff Williams and Gary Mirams  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Journal of Pharmacological and Toxicological Methods</em>.
        
            Vol. 75.
        
                Pages 10&#x2212;16.
            2015.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication9544-abstract.html">
			Details <span class="sr-only" > about <em> A web portal for in&#x2212;silico action potential predictions  </em></span> </a> |
			<a href="/publications/publication9544.bib">
			BibTeX  <span class="sr-only" > data for <em> A web portal for in&#x2212;silico action potential predictions  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1016/j.vascn.2015.05.002">
		DOI (10.1016/j.vascn.2015.05.002)
		</a> 
					| <a href="http://dx.doi.org/10.1016/j.vascn.2015.05.002"> Link <span class="sr-only" > to <em> A web portal for in&#x2212;silico action potential predictions  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            An integrative computational model for intestinal tissue renewal </strong> </p>
	    <p class="publicationAuthors"> <em> Van Leeuwen&#x201a; Ingeborg MM&#x201a; GR Mirams&#x201a; Alex Walter&#x201a; A Fletcher&#x201a; P Murray&#x201a; J Osborne&#x201a; S Varma&#x201a; SJ Young&#x201a; J Cooper&#x201a; B Doyle and others  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Cell proliferation</em>.
        
            Vol. 42.
        
            No. 5.
        
                Pages 617&#x2013;636.
            2009.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication2848-abstract.html">
			Details <span class="sr-only" > about <em> An integrative computational model for intestinal tissue renewal  </em></span> </a> |
			<a href="/publications/publication2848.bib">
			BibTeX  <span class="sr-only" > data for <em> An integrative computational model for intestinal tissue renewal  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1111/j.1365-2184.2009.00627.x">
		DOI (10.1111/j.1365-2184.2009.00627.x)
		</a> 
		
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	<p class="publicationTitle"> <strong>
            Application of Human Stem Cell&#x2212;derived Cardiomyocytes in Safety Pharmacology Requires Caution Beyond hERG </strong> </p>
	    <p class="publicationAuthors"> <em> M. Jonsson&#x201a; M.A. Vos&#x201a; G.R. Mirams&#x201a; G. Duker&#x201a; P. Sartipy&#x201a; T.P. de Boer and T.A.B van Veen  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Journal of Molecular and Cellular Cardiology</em>.
        
            Vol. 52.
        
            No. 5.
        
                Pages 998&#x2212;1008.
            2012.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication5834-abstract.html">
			Details <span class="sr-only" > about <em> Application of Human Stem Cell&#x2212;derived Cardiomyocytes in Safety Pharmacology Requires Caution Beyond hERG  </em></span> </a> |
			<a href="/publications/publication5834.bib">
			BibTeX  <span class="sr-only" > data for <em> Application of Human Stem Cell&#x2212;derived Cardiomyocytes in Safety Pharmacology Requires Caution Beyond hERG  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1016/j.yjmcc.2012.02.002">
		DOI (10.1016/j.yjmcc.2012.02.002)
		</a> 
					| <a href="http://www.sciencedirect.com/science/article/pii/S0022282812000843"> Link <span class="sr-only" > to <em> Application of Human Stem Cell&#x2212;derived Cardiomyocytes in Safety Pharmacology Requires Caution Beyond hERG  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            Application of cardiac electrophysiology simulations to pro&#x2212;arrhythmic safety testing </strong> </p>
	    <p class="publicationAuthors"> <em> Gary R. Mirams&#x201a; Mark R. Davies&#x201a; Yi Cui&#x201a; Peter Kohl and Denis Noble  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>British Journal of Pharmacology</em>.
        
            Vol. 167.
        
            No. 5.
        
                Pages 932&#x2212;945.
            2012.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication5985-abstract.html">
			Details <span class="sr-only" > about <em> Application of cardiac electrophysiology simulations to pro&#x2212;arrhythmic safety testing  </em></span> </a> |
			<a href="/publications/publication5985.bib">
			BibTeX  <span class="sr-only" > data for <em> Application of cardiac electrophysiology simulations to pro&#x2212;arrhythmic safety testing  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1111/j.1476-5381.2012.02020.x">
		DOI (10.1111/j.1476-5381.2012.02020.x)
		</a> 
		
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	<p class="publicationTitle"> <strong>
            Application of stochastic phenomenological modelling to cell&#x2212;to&#x2212;cell and beat&#x2212;to&#x2212;beat electrophysiological variability in cardiac tissue </strong> </p>
	    <p class="publicationAuthors"> <em> John Walmsley&#x201a; Gary R Mirams&#x201a; Joe Pitt&#x2212;Francis&#x201a; Blanca Rodriguez and Kevin Burrage  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Journal of theoretical biology</em>.
        
            Vol. 365.
        
                Pages 325&#x2013;336.
            2015.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication9027-abstract.html">
			Details <span class="sr-only" > about <em> Application of stochastic phenomenological modelling to cell&#x2212;to&#x2212;cell and beat&#x2212;to&#x2212;beat electrophysiological variability in cardiac tissue  </em></span> </a> |
			<a href="/publications/publication9027.bib">
			BibTeX  <span class="sr-only" > data for <em> Application of stochastic phenomenological modelling to cell&#x2212;to&#x2212;cell and beat&#x2212;to&#x2212;beat electrophysiological variability in cardiac tissue  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1016/j.jtbi.2014.10.029">
		DOI (10.1016/j.jtbi.2014.10.029)
		</a> 
		
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	<p class="publicationTitle"> <strong>
            Ca2+ Channel Re&#x2212;localization to Plasma&#x2212;Membrane Microdomains Strengthens Activation of Ca2+&#x2212;Dependent Nuclear Gene Expression </strong> </p>
	    <p class="publicationAuthors"> <em> Krishna Samanta&#x201a; Pulak Kar&#x201a; Gary R. Mirams and Anant B. Parekh  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Cell Reports</em>.
        
            Vol. 12.
        
            No. 2.
        
                Pages 203&#x2212;216.
            2015.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication9626-abstract.html">
			Details <span class="sr-only" > about <em> Ca2+ Channel Re&#x2212;localization to Plasma&#x2212;Membrane Microdomains Strengthens Activation of Ca2+&#x2212;Dependent Nuclear Gene Expression  </em></span> </a> |
			<a href="/publications/publication9626.bib">
			BibTeX  <span class="sr-only" > data for <em> Ca2+ Channel Re&#x2212;localization to Plasma&#x2212;Membrane Microdomains Strengthens Activation of Ca2+&#x2212;Dependent Nuclear Gene Expression  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1016/j.celrep.2015.06.018">
		DOI (10.1016/j.celrep.2015.06.018)
		</a> 
					| <a href="http://dx.doi.org/10.1016/j.celrep.2015.06.018"> Link <span class="sr-only" > to <em> Ca2+ Channel Re&#x2212;localization to Plasma&#x2212;Membrane Microdomains Strengthens Activation of Ca2+&#x2212;Dependent Nuclear Gene Expression  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            Cardiac Tissue Slices: Preparation&#x201a; Handling&#x201a; and Successful Optical Mapping </strong> </p>
	    <p class="publicationAuthors"> <em> K Wang&#x201a; P Lee&#x201a; GR Mirams&#x201a; P Sarathchandra&#x201a; T Borg&#x201a; DJ Gavaghan&#x201a; P Kohl and C Bollensdorff  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>American Journal of Physiology: Heart and Circulatory Physiology</em>.
        
            Vol. 308.
        
                Pages H1112&#x2212;H1125.
            2015.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication9289-abstract.html">
			Details <span class="sr-only" > about <em> Cardiac Tissue Slices: Preparation&#x201a; Handling&#x201a; and Successful Optical Mapping  </em></span> </a> |
			<a href="/publications/publication9289.bib">
			BibTeX  <span class="sr-only" > data for <em> Cardiac Tissue Slices: Preparation&#x201a; Handling&#x201a; and Successful Optical Mapping  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1152/ajpheart.00556.2014">
		DOI (10.1152/ajpheart.00556.2014)
		</a> 
					| <a href="http://ajpheart.physiology.org/content/308/9/H1112"> Link <span class="sr-only" > to <em> Cardiac Tissue Slices: Preparation&#x201a; Handling&#x201a; and Successful Optical Mapping  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            Cellular cardiac electrophysiology modelling with Chaste and CellML </strong> </p>
	    <p class="publicationAuthors"> <em> Jonathan Cooper&#x201a; Raymond Spiteri and Gary Mirams  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Frontiers in Physiology</em>.
        
            Vol. 5.
        
                Pages 511.
            January,
            2015.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication9126-abstract.html">
			Details <span class="sr-only" > about <em> Cellular cardiac electrophysiology modelling with Chaste and CellML  </em></span> </a> |
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			BibTeX  <span class="sr-only" > data for <em> Cellular cardiac electrophysiology modelling with Chaste and CellML  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.3389/fphys.2014.00511">
		DOI (10.3389/fphys.2014.00511)
		</a> 
					| <a href="http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00511"> Link <span class="sr-only" > to <em> Cellular cardiac electrophysiology modelling with Chaste and CellML  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            Chaste: a test&#x2212;driven approach to software development for biological modelling </strong> </p>
	    <p class="publicationAuthors"> <em> Joe Pitt&#x2212;Francis&#x201a; Pras Pathmanathan&#x201a; Miguel O Bernabeu&#x201a; Rafel Bordas&#x201a; Jonathan Cooper&#x201a; Alexander G Fletcher&#x201a; Gary R Mirams&#x201a; Philip Murray&#x201a; James M Osborne&#x201a; Alex Walter and others  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Computer Physics Communications</em>.
        
            Vol. 180.
        
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                Pages 2452&#x2013;2471.
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        		<p class="publicationlinks"> <a
        
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			Details <span class="sr-only" > about <em> Chaste: a test&#x2212;driven approach to software development for biological modelling  </em></span> </a> |
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			 | <a
		href="http://dx.doi.org/10.1016/j.cpc.2009.07.019">
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	<p class="publicationTitle"> <strong>
            Chaste: an open source C++ library for computational physiology and biology </strong> </p>
	    <p class="publicationAuthors"> <em> Gary R Mirams&#x201a; Christopher J Arthurs&#x201a; Miguel O Bernabeu&#x201a; Rafel Bordas&#x201a; Jonathan Cooper&#x201a; Alberto Corrias&#x201a; Yohan Davit&#x201a; Sara&#x2212;Jane Dunn&#x201a; Alexander G Fletcher&#x201a; Daniel G Harvey and others  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>PLoS computational biology</em>.
        
            Vol. 9.
        
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                Pages e1002970.
            2013.
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        		<p class="publicationlinks"> <a
        
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			Details <span class="sr-only" > about <em> Chaste: an open source C++ library for computational physiology and biology  </em></span> </a> |
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			 | <a
		href="http://dx.doi.org/10.1371/journal.pcbi.1002970">
		DOI (10.1371/journal.pcbi.1002970)
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	<p class="publicationTitle"> <strong>
            Computational assessment of drug&#x2212;induced effects on the electrocardiogram: from ion channel block to body surface potentials </strong> </p>
	    <p class="publicationAuthors"> <em> N Zemzemi&#x201a; MO Bernabeu&#x201a; J Saiz&#x201a; J Cooper&#x201a; P Pathmanathan&#x201a; GR Mirams&#x201a; J Pitt&#x2212;Francis and B Rodriguez  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>British Journal of Pharmacology</em>.
        
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        		<p class="publicationlinks"> <a
        
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		href="http://dx.doi.org/10.1111/j.1476-5381.2012.02200.x">
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	<p class="publicationTitle"> <strong>
            Connexin 43 contributes to electrotonic conduction across scar tissue in the intact heart </strong> </p>
	    <p class="publicationAuthors"> <em> VM Mahoney&#x201a; V Mezzano&#x201a; GR Mirams&#x201a; K Maass&#x201a; Z Li&#x201a; M Cerrone&#x201a; C Vasquez&#x201a; A Bapat&#x201a; M Delmar and GE Morley  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Scientific Reports</em>.
        
            Vol. 6.
        
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        		<p class="publicationlinks"> <a
        
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			 | <a
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	<p class="publicationTitle"> <strong>
            Control of NFAT Isoform Activation and NFAT&#x2212;Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals </strong> </p>
	    <p class="publicationAuthors"> <em> P Kar&#x201a; GR Mirams&#x201a; HC Christian and AB Parekh  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Molecular Cell</em>.
        
            Vol. 64.
        
            No. 4.
        
                Pages 746&#x2212;759.
            2016.
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			Details <span class="sr-only" > about <em> Control of NFAT Isoform Activation and NFAT&#x2212;Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals  </em></span> </a> |
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		href="http://dx.doi.org/10.1016/j.molcel.2016.11.011">
		DOI (10.1016/j.molcel.2016.11.011)
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					| <a href="http://www.sciencedirect.com/science/article/pii/S1097276516307195"> Link <span class="sr-only" > to <em> Control of NFAT Isoform Activation and NFAT&#x2212;Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            Distinguishing possible mechanisms for auxin&#x2212;mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins&#x201a; and two target gene&#x2212;sets </strong> </p>
	    <p class="publicationAuthors"> <em> L. J. Bridge&#x201a; G. R. Mirams&#x201a; M. L. Kieffer&#x201a; J. R. King and S. Kepinski  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Mathematical Biosciences</em>.
        
            Vol. 235.
        
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                Pages 32&#x2212;44.
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        		<p class="publicationlinks"> <a
        
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	<p class="publicationTitle"> <strong>
            Estimation of conductivity tensors from human ventricular optical mapping recordings </strong> </p>
	    <p class="publicationAuthors"> <em> J. Walmsley&#x201a; G.R. Mirams&#x201a; I.R. Efimov&#x201a; K. Burrage and B. Rodriguez  </em> </p>
	
	<p class="publicationDetails"> 
            In  
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            Functional Imaging and Modeling of the Heart</em>.
        
            Vol. 7495.
        
                Pages 224&#x2013;231.
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        		<p class="publicationlinks"> <a
        
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	<p class="publicationTitle"> <strong>
            Evaluation of an In Silico Cardiac Safety Assay: Using Ion Channel Screening Data to Predict QT Interval Changes in the Rabbit Ventricular Wedge </strong> </p>
	    <p class="publicationAuthors"> <em> Kylie A. Beattie&#x201a; Chris Luscombe&#x201a; Geoff Williams&#x201a; Jordi Munoz&#x2212;Muriedas&#x201a; David J. Gavaghan&#x201a; Yi Cui and Gary R. Mirams  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Journal of Pharmacological and Toxicological Methods</em>.
        
            Vol. 68.
        
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                Pages 88&#x2212;96.
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        		<p class="publicationlinks"> <a
        
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			Details <span class="sr-only" > about <em> Evaluation of an In Silico Cardiac Safety Assay: Using Ion Channel Screening Data to Predict QT Interval Changes in the Rabbit Ventricular Wedge  </em></span> </a> |
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			 | <a
		href="http://dx.doi.org/10.1016/j.vascn.2013.04.004">
		DOI (10.1016/j.vascn.2013.04.004)
		</a> 
					| <a href="http://www.sciencedirect.com/science/article/pii/S105687191300244X"> Link <span class="sr-only" > to <em> Evaluation of an In Silico Cardiac Safety Assay: Using Ion Channel Screening Data to Predict QT Interval Changes in the Rabbit Ventricular Wedge  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            Evaluation of computational modelling as a preclinical proarrhythmic safety assay </strong> </p>
	    <p class="publicationAuthors"> <em> G Mirams&#x201a; K Beattie&#x201a; Y Cui&#x201a; C Luscombe&#x201a; G Williams&#x201a; D Gavaghan and N McMahon  </em> </p>
	
	<p class="publicationDetails"> 
            Vol. 86.
        
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			 | <a
		href="http://dx.doi.org/10.1016/j.vascn.2013.01.081">
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	<p class="publicationTitle"> <strong>
            Hierarchical Bayesian inference for ion channel screening dose&#x2212;response data </strong> </p>
	    <p class="publicationAuthors"> <em> RH Johnstone&#x201a; R Bardenet&#x201a; DJ Gavaghan and GR Mirams  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Wellcome Open Research</em>.
        
            Vol. 1.
        
                Pages 6.
            2016.
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        		<p class="publicationlinks"> <a
        
            		href="/publications/publication10776-abstract.html">
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			 | <a
		href="http://dx.doi.org/10.12688/wellcomeopenres.9945.1">
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		</a> 
					| <a href="https://wellcomeopenresearch.org/articles/1-6/v1"> Link <span class="sr-only" > to <em> Hierarchical Bayesian inference for ion channel screening dose&#x2212;response data  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            High&#x2212;throughput functional curation of cellular electrophysiology models </strong> </p>
	    <p class="publicationAuthors"> <em> Niederer S.A. Cooper J. Mirams G.R.  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Progress in Biophysics and Molecular Biology</em>.
        
            Vol. 107.
        
                Pages 11 &#x2212; 20.
            2011.
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        		<p class="publicationlinks"> <a
        
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			 | <a
		href="http://dx.doi.org/10.1016/j.pbiomolbio.2011.06.003">
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	<p class="publicationTitle"> <strong>
            Hydroxychloroquine reduces heart rate by modulating the hyperpolarisation activated current &#x2018;If&#x2019;: Novel electrophysiological insights and therapeutic potential </strong> </p>
	    <p class="publicationAuthors"> <em> R.A. Capel&#x201a; N Herring&#x201a; M Kalla&#x201a; A Yavari&#x201a; G.R. Mirams&#x201a; G. Douglas&#x201a; G. Bub&#x201a; K. Channon&#x201a; D.J. Paterson&#x201a; D. Terrar and R&#x2212;A Burton  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Heart Rhythm</em>.
        
            Vol. 12.
        
            No. 10.
        
                Pages 2186&#x2013;2194.
            2015.
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        		<p class="publicationlinks"> <a
        
            		href="/publications/publication9625-abstract.html">
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			 | <a
		href="http://dx.doi.org/10.1016/j.hrthm.2015.05.027">
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					| <a href="http://dx.doi.org/10.1016/j.hrthm.2015.05.027"> Link <span class="sr-only" > to <em> Hydroxychloroquine reduces heart rate by modulating the hyperpolarisation activated current &#x2018;If&#x2019;: Novel electrophysiological insights and therapeutic potential  </em></span> </a>
  				
		
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	<p class="publicationTitle"> <strong>
            Is it time for in silico simulation of drug cardiac side effects? </strong> </p>
	    <p class="publicationAuthors"> <em> G.R. Mirams and D. Noble  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Annals of the New York Academy of Sciences</em>.
        
            Vol. 1245.
        
                Pages 44&#x2212;47.
            2011.
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            		href="/publications/publication5475-abstract.html">
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			 | <a
		href="http://dx.doi.org/10.1111/j.1749-6632.2011.06324.x">
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	<p class="publicationTitle"> <strong>
            L&#x2212;TYPE CALCIUM CHANNELS AND CALCIUM REGULATION IN VENTRICULAR MYOCYTES: IN SILICO STUDIES </strong> </p>
	    <p class="publicationAuthors"> <em> A. Sher&#x201a; G. Mirams&#x201a; DJ Gavaghan&#x201a; D. Noble and M. Fink  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>JOURNAL OF PHYSIOLOGICAL SCIENCES&#xa0;&#xa0;&#xa0;&#xa0;</em>.
        
            Vol. 59.
        
                Pages 259&#x2013;259.
            2009.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication4227-abstract.html">
			Details <span class="sr-only" > about <em> L&#x2212;TYPE CALCIUM CHANNELS AND CALCIUM REGULATION IN VENTRICULAR MYOCYTES: IN SILICO STUDIES  </em></span> </a> |
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	<p class="publicationTitle"> <strong>
            Minimum information about a cardiac electrophysiology experiment (MICEE): Standardised reporting for model reproducibility&#x201a; interoperability&#x201a; and data sharing </strong> </p>
	    <p class="publicationAuthors"> <em> T.A. Quinn&#x201a; S. Granite&#x201a; M.A. Allessie&#x201a; C. Antzelevitch&#x201a; C. Bollensdorff&#x201a; G. Bub&#x201a; R.A.B. Burton&#x201a; E. Cerbaig&#x201a; P.S. Chen&#x201a; M. Delmar&#x201a; D. DiFrancesco&#x201a; Y.E. Earm&#x201a; I.R. Efimov&#x201a; M. Egger&#x201a; E. Entcheva&#x201a; M. Fink&#x201a; R. Fischmeister&#x201a; M.R. Franz&#x201a; A. Garny&#x201a; W.R. Giles&#x201a; T. Hannes&#x201a; S.E. Harding&#x201a; P.J. Hunter&#x201a; G. Iribe&#x201a; J. Jalife&#x201a; C.R. Johnson&#x201a; R.S. Kass&#x201a; I. Kodama&#x201a; G. Koren&#x201a; P. Lord&#x201a; V.S. Markhasin&#x201a; S. Matsuoka&#x201a; A.D. McCulloch&#x201a; G.R. Mirams&#x201a; G.E. Morley&#x201a; S. Nattel&#x201a; D. Noble&#x201a; S.P. Olesen&#x201a; A.V. Panfilov&#x201a; N.A. Trayanova&#x201a; U. Ravens&#x201a; S. Richard&#x201a; D.S. Rosenbaum&#x201a; Y. Rudy&#x201a; F. Sachs&#x201a; F.B. Sachse&#x201a; D.A. Saint&#x201a; U. Schotten&#x201a; O. Solovyova&#x201a; P. Taggart&#x201a; L. Tung&#x201a; A. Varr&#xf3;&#x201a; P.G. Volders&#x201a; K. Wang&#x201a; J.N. Weiss&#x201a; E. Wettwer&#x201a; E. White&#x201a; R. Wilders&#x201a; R.L. Winslow and P. Kohl  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Progress in Biophysics and Molecular Biology</em>.
        
            Vol. 107.
        
                Pages 4 &#x2212; 10.
            2011.
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        		<p class="publicationlinks"> <a
        
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	<p class="publicationTitle"> <strong>
            Modelling Spatially Regulated beta&#x2212;Catenin Dynamics and Invasion in Intestinal Crypts </strong> </p>
	    <p class="publicationAuthors"> <em> Philip J. Murray&#x201a; JW Kang&#x201a; Gary R. Mirams&#x201a; SY Shin&#x201a; Helen M. Byrne&#x201a; Philip K. Maini and KH Cho  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Biophysical Journal</em>.
        
            Vol. 99.
        
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	<p class="publicationTitle"> <strong>
            Novel approaches to assessing cardiac safety&#x2212;proceedings of a workshop: regulators&#x201a; industry and academia discuss the future of in silico cardiac modelling to predict the proarrhythmic safety of drugs. </strong> </p>
	    <p class="publicationAuthors"> <em> K. Fletcher&#x201a; R.R. Shah&#x201a; A. Thomas&#x201a; F. Tobin&#x201a; B. Rodriguez&#x201a; G.R. Mirams&#x201a; J. Saiz and D. Noble  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Drug safety: an international journal of medical toxicology and drug experience</em>.
        
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	<p class="publicationTitle"> <strong>
            Phenomenological modeling of cell&#x2212;to&#x2212;cell and beat&#x2212;to&#x2212;beat variability in isolated Guinea Pig ventricular myocytes </strong> </p>
	    <p class="publicationAuthors"> <em> J. Walmsley&#x201a; G.R. Mirams&#x201a; M. Bahoshy&#x201a; C. Bollensdorff&#x201a; B. Rodriguez and K. Burrage  </em> </p>
	
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	<p class="publicationTitle"> <strong>
            Prediction of Thorough QT study results using action potential simulations based on ion channel screens </strong> </p>
	    <p class="publicationAuthors"> <em> GR Mirams&#x201a; MR Davies&#x201a; SJ Brough&#x201a; MH Bridgland&#x2212;Taylor&#x201a; Y Cui&#x201a; DJ Gavaghan and N Abi&#x2212;Gerges  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Journal of Pharmacological & Toxicological Methods</em>.
        
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                Pages 246&#x2212;254.
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	<p class="publicationTitle"> <strong>
            Recent developments in using mechanistic cardiac modelling for drug safety evaluation </strong> </p>
	    <p class="publicationAuthors"> <em> MR Davies&#x201a; K Wang&#x201a; GR Mirams&#x201a; A Caruso&#x201a; D Noble&#x201a; A Walz&#x201a; T Lav&#xe9;&#x201a; F Schuler&#x201a; T Singer and L Polonchuk  </em> </p>
	
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        In <em>Drug Discovery Today</em>.
        
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                Pages 924&#x2013;938.
            2016.
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	<p class="publicationTitle"> <strong>
            Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk </strong> </p>
	    <p class="publicationAuthors"> <em> G. R. Mirams&#x201a; Y. Cui&#x201a; A. Sher&#x201a; M. Fink&#x201a; J. Cooper&#x201a; B. M. Heath&#x201a; N. C. McMahon&#x201a; D. J. Gavaghan and D. Noble  </em> </p>
	
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        In <em>Cardiovascular Research</em>.
        
            Vol. 91.
        
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			 | <a
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	<p class="publicationTitle"> <strong>
            Stochasticity in Action Potential duration Enhances Dispersion of Repolarisation at Fast Pacing Rates </strong> </p>
	    <p class="publicationAuthors"> <em> John Walmsley&#x201a; Kevin Burrage&#x201a; Joe M. Pitt&#x2212;Francis&#x201a; Gary R. Mirams and Blanca Rodriguez  </em> </p>
	
	<p class="publicationDetails"> 
            Vol. 102.
        
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                Pages 592a&#x2212;593a.
            2012.
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	<p class="publicationTitle"> <strong>
            Subcellular phenomena in colorectal cancer </strong> </p>
	    <p class="publicationAuthors"> <em> Gary R. Mirams  </em> </p>
	
	<p class="publicationDetails">  PhD Thesis University of Nottingham.
        2008.
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			Details <span class="sr-only" > about <em> Subcellular phenomena in colorectal cancer  </em></span> </a> |
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	<p class="publicationTitle"> <strong>
            Ten simple rules for effective computational research </strong> </p>
	    <p class="publicationAuthors"> <em> James M Osborne&#x201a; Miguel O Bernabeu&#x201a; Maria Bruna&#x201a; Ben Calderhead&#x201a; Jonathan Cooper&#x201a; Neil Dalchau&#x201a; Sara&#x2212;Jane Dunn&#x201a; Alexander G Fletcher&#x201a; Robin Freeman&#x201a; Derek Groen and others  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>PLoS Computational Biology</em>.
        
            Vol. 10.
        
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	<p class="publicationTitle"> <strong>
            The Cardiac Electrophysiology Web Lab </strong> </p>
	    <p class="publicationAuthors"> <em> Jonathan Cooper&#x201a; Martin Scharm and Gary Mirams  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Biophysical Journal</em>.
        
            Vol. 110.
        
            No. 2.
        
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	<p class="publicationTitle"> <strong>
            The significant effect of the choice of ionic current integration method in cardiac electrophysiological simulations </strong> </p>
	    <p class="publicationAuthors"> <em> P. Pathmanathan G.R. Mirams J.A. Southern and J.P. Whiteley  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>International Journal for Numerical Methods in Biomedical Engineering</em>.
        
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	<p class="publicationTitle"> <strong>
            Uncertainty and variability in models of the cardiac action potential: can we build trustworthy models? </strong> </p>
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                Pages 49&#x2212;62.
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	<p class="publicationTitle"> <strong>
            Variability in high&#x2212;throughput ion channel screening data and consequences for cardiac safety assessment </strong> </p>
	    <p class="publicationAuthors"> <em> Ryan C. Elkins&#x201a; Mark R. Davies&#x201a; Stephen J. Brough&#x201a; David J. Gavaghan&#x201a; Yi Cui&#x201a; Najah Abi&#x2212;Gerges and Gary R. Mirams  </em> </p>
	
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                Pages 112&#x2212;122.
            2013.
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	<p class="publicationTitle"> <strong>
            White Paper: Computational Cardiology and Risk Stratification for Sudden Cardiac Death: One of the Grand Challenges for Cardiology in the 21st Century. </strong> </p>
	    <p class="publicationAuthors"> <em> AP Hill&#x201a; MD Perry&#x201a; N Abi&#x2212;Gerges&#x201a; J&#x2212;P Couderc&#x201a; B Fermini&#x201a; JC Hancox&#x201a; BC Knollmann&#x201a; GR Mirams&#x201a; J Skinner&#x201a; W Zareba and JI Vandenberg  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Journal of Physiology</em>.
        2016.
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	<p class="publicationTitle"> <strong>
            White Paper: Uncertainty and variability in computational and mathematical models of cardiac physiology </strong> </p>
	    <p class="publicationAuthors"> <em> GR Mirams&#x201a; P Pathmanathan&#x201a; RA Gray&#x201a; P Challenor and RH Clayton  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>Journal of Physiology</em>.
        2016.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication10343-abstract.html">
			Details <span class="sr-only" > about <em> White Paper: Uncertainty and variability in computational and mathematical models of cardiac physiology  </em></span> </a> |
			<a href="/publications/publication10343.bib">
			BibTeX  <span class="sr-only" > data for <em> White Paper: Uncertainty and variability in computational and mathematical models of cardiac physiology  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1113/JP271671">
		DOI (10.1113/JP271671)
		</a> 
		
		</div> 
	</div> 
	
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				[45] 
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			class="col-xs-11"
		>
			
	
	<p class="publicationTitle"> <strong>
            mRNA expression levels in failing human hearts predict cellular electrophysiological remodelling: A population&#x2212;based simulation study </strong> </p>
	    <p class="publicationAuthors"> <em> J. Walmsley&#x201a; J.F. Rodriguez&#x201a; G.R. Mirams&#x201a; K. Burrage&#x201a; I.R. Efimov and B. Rodriguez  </em> </p>
	
	<p class="publicationDetails"> 
        In <em>PLoS ONE</em>.
        
            Vol. 8.
        
            No. 2.
        
                Pages e56359.
            2013.
        </p>
	
        		<p class="publicationlinks"> <a
        
            		href="/publications/publication6307-abstract.html">
			Details <span class="sr-only" > about <em> mRNA expression levels in failing human hearts predict cellular electrophysiological remodelling: A population&#x2212;based simulation study  </em></span> </a> |
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			BibTeX  <span class="sr-only" > data for <em> mRNA expression levels in failing human hearts predict cellular electrophysiological remodelling: A population&#x2212;based simulation study  </em></span>   </a>
			
			 | <a
		href="http://dx.doi.org/10.1371/journal.pone.0056359">
		DOI (10.1371/journal.pone.0056359)
		</a> 
		
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